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Adjuvant mRNA-4157 plus pembrolizumab prolonged recurrence-free survival versus pembrolizumab monotherapy in patients with resected high-risk melanoma and showed a manageable safety profile. These results provide evidence that an mRNA-based individualised neoantigen therapy might be beneficial in the adjuvant setting.

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Such ‘non-mutational neoantigens’ can arise from several post-transcriptional and post-translational mechanisms, including epitope mimicry, the usage of non-canonical initiation codons ...

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